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Direct and tumor microenvironment mediated influences of 5'-deoxy-5'-(methylthio)adenosine on tumor progression of malignant melanoma

Stevens, Axel Peter ; Spangler, Barbara ; Wallner, Susanne ; Kreutz, Marina ; Dettmer, Katja ; Oefner, Peter J. ; Bosserhoff, Anja-Katrin


Recent studies have shown that a loss of methylthioadenosine phosphorylase (MTAP) gene expression exerts a tumor-promoting effect, including induction of invasiveness, enhanced cell proliferation, and resistance against cytokines. To date, the molecular mechanisms underlying these effects remain unknown. Since the loss of MTAP expression resulted in induced secretion of ...


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