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Direct and tumor microenvironment mediated influences of 5'-deoxy-5'-(methylthio)adenosine on tumor progression of malignant melanoma

Stevens, Axel Peter, Spangler, Barbara, Wallner, Susanne, Kreutz, Marina, Dettmer, Katja, Oefner, Peter J. and Bosserhoff, Anja-Katrin (2009) Direct and tumor microenvironment mediated influences of 5'-deoxy-5'-(methylthio)adenosine on tumor progression of malignant melanoma. Journal of cellular biochemistry 106 (2), pp. 210-219.

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Abstract

Recent studies have shown that a loss of methylthioadenosine phosphorylase (MTAP) gene expression exerts a tumor-promoting effect, including induction of invasiveness, enhanced cell proliferation, and resistance against cytokines. To date, the molecular mechanisms underlying these effects remain unknown. Since the loss of MTAP expression resulted in induced secretion of ...

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Item type:Article
Date:February 2009
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
19097084PubMed ID
10.1002/jcb.21984DOI
Classification:
NotationType
Deoxyadenosines/pharmacologyMESH
Disease ProgressionMESH
FibroblastsMESH
Melanoma/pathologyMESH
Signal Transduction/drug effectsMESH
Thionucleosides/pharmacologyMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30659
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