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Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location

Filatova, Alina, Leyerer, Marina, Gorboulev, Valentin, Chintalapati, Chakravarthi, Reinders, Yvonne, Müller, Thomas D., Srinivasan, Aruna, Hübner, Stefan and Koepsell, Hermann (2009) Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location. Traffic 10 (11), pp. 1599-1618.

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Abstract

The gene product of RSC1A1, RS1, participates in the regulation of the Na(+)-D-glucose cotransporter SGLT1. RS1 inhibits release of SGLT1 from the trans Golgi network. In subconfluent LLC-PK(1) cells, RS1 migrates into the nucleus and modulates transcription of SGLT1, whereas most confluent cells do not contain RS1 in the nuclei. We showed that confluence-dependent nuclear location of RS1 is ...

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Item type:Article
Date:November 2009
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
19765263PubMed ID
10.1111/j.1600-0854.2009.00982.xDOI
Classification:
NotationType
Active Transport, Cell NucleusMESH
AnimalsMESH
Cell CycleMESH
Cell Nucleus/metabolismMESH
Culture Media, Serum-FreeMESH
Genetic VectorsMESH
Glucose/metabolismMESH
Green Fluorescent Proteins/metabolismMESH
Karyopherins/metabolismMESH
LLC-PK1 CellsMESH
Membrane Transport Proteins/metabolismMESH
Monosaccharide Transport Proteins/metabolismMESH
Nuclear Localization Signals/metabolismMESH
PhosphorylationMESH
Protein Kinase C/metabolismMESH
Protein Structure, TertiaryMESH
Protein Transport/physiologyMESH
Recombinant Fusion Proteins/metabolismMESH
Ribonucleoproteins, Small Nuclear/metabolismMESH
Sodium/metabolismMESH
Sodium-Glucose Transporter 1/metabolismMESH
SwineMESH
Time FactorsMESH
TransfectionMESH
trans-Golgi Network/metabolismMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:30674
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