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Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location

Filatova, Alina ; Leyerer, Marina ; Gorboulev, Valentin ; Chintalapati, Chakravarthi ; Reinders, Yvonne ; Müller, Thomas D. ; Srinivasan, Aruna ; Hübner, Stefan ; Koepsell, Hermann


The gene product of RSC1A1, RS1, participates in the regulation of the Na(+)-D-glucose cotransporter SGLT1. RS1 inhibits release of SGLT1 from the trans Golgi network. In subconfluent LLC-PK(1) cells, RS1 migrates into the nucleus and modulates transcription of SGLT1, whereas most confluent cells do not contain RS1 in the nuclei. We showed that confluence-dependent nuclear location of RS1 is ...


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