Explorative data analysis of MCL reveals gene expression networks implicated in survival and prognosis supported by explorative CGH analysis

URN to cite this document:: urn:nbn:de:bvb:355-epub-306782
DOI to cite this document:: 10.5283/epub.30678

Blenk, Steffen ; Engelmann, Julia C. ; Pinkert, Stefan ; Weniger, Markus ; Schultz, Jörg ; Rosenwald, Andreas ; Müller-Hermelink, Hans K. ; Müller, Tobias ; Dandekar, Thomas

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Date of publication of this fulltext: 20 Aug 2014 08:19

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Abstract

BACKGROUND: Mantle cell lymphoma (MCL) is an incurable B cell lymphoma and accounts for 6% of all non-Hodgkin's lymphomas. On the genetic level, MCL is characterized by the hallmark translocation t(11;14) that is present in most cases with few exceptions. Both gene expression and comparative genomic hybridization (CGH) data vary considerably between patients with implications for their ...