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Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell

Montesinos-Rongen, M. ; Brunn, A. ; Bentink, Stefan ; Basso, K. ; Lim, W. K. ; Klapper, Wolfram ; Schaller, C. ; Reifenberger, G. ; Rubenstein, J. ; Wiestler, O. D. ; Spang, Rainer ; Dalla-Favera, R. ; Siebert, Reiner ; Deckert, M.



Abstract

To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated PCNSL (i) to display gene expression patterns most closely related to late germinal ...

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