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Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell

Montesinos-Rongen, M, ; Brunn, A, ; Bentink, Stefan ; Basso, K, ; Lim, W, K, ; Klapper, Wolfram ; Schaller, C, ; Reifenberger, G, ; Rubenstein, J, ; Wiestler, O, D, ; Spang, Rainer ; Dalla-Favera, R, ; Siebert, Reiner ; Deckert, M,



Abstract

To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated PCNSL (i) to display gene expression patterns most closely related to late germinal ...

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