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Ataxia telangiectasia-mutated gene is a possible biomarker for discrimination of infiltrative deep penetrating nevi and metastatic vertical growth phase melanoma

Roesch, Alexander ; Becker, Bernd ; Bentink, Stefan ; Spang, Rainer ; Vogl, Annegret ; Hagen, Ilja ; Landthaler, Michael ; Vogt, Thomas


The deep penetrating nevus (DPN) is a variant of benign melanocytic nevus with clinical and histologic features mimicking vertical growth phase, nodular malignant melanoma (NMM). Because fatal misdiagnosis such as NMM occurs in 29% to 40% of the DPN, molecular differentiation markers are highly desirable. Beyond the clinical demand for precise diagnosis and diagnosis-adapted, preventive ...


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