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Gene expression signatures for tumor progression, tumor subtype, and tumor thickness in laser-microdissected melanoma tissues

Jaeger, Jochen ; Koczan, Dirk ; Thiesen, Hans-Juergen ; Ibrahim, Saleh M. ; Gross, Gerd ; Spang, Rainer ; Kunz, Manfred



Abstract

PURPOSE: To better understand the molecular mechanisms of malignant melanoma progression and metastasis, gene expression profiling was done of primary melanomas and melanoma metastases. EXPERIMENTAL DESIGN: Tumor cell-specific gene expression in 19 primary melanomas and 22 melanoma metastases was analyzed using oligonucleotide microarrays after laser-capture microdissection of melanoma cells. ...

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