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Gene expression shift towards normal B cells, decreased proliferative capacity and distinct surface receptors characterize leukemic blasts persisting during induction therapy in childhood acute lymphoblastic leukemia

Rhein, P. ; Scheid, S. ; Ratei, R. ; Hagemeier, C. ; Seeger, K. ; Kirschner-Schwabe, R. ; Moericke, A. ; Schrappe, M. ; Spang, Rainer ; Ludwig, W.-D. ; Karawajew, L.


In childhood acute lymphoblastic leukemia (ALL), persistence of leukemic blasts during therapy is of crucial prognostic significance. In the present study, we address molecular and cell biologic features of blasts persisting after 1 week of induction glucocorticoid therapy. Genome-wide gene expression analysis of leukemic samples from precursor B-cell ALL patients (n=18) identified a set of genes ...


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