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Nanoparticle multivalency counterbalances the ligand affinity loss upon PEGylation

Hennig, Robert, Pollinger, Klaus, Veser, Anika, Breunig, Miriam and Goepferich, Achim (2014) Nanoparticle multivalency counterbalances the ligand affinity loss upon PEGylation. Journal of Controlled Release 194, pp. 20-27.

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Abstract

The conjugation of receptor ligands to shielded nanoparticles is a widely used strategy to precisely control nanoparticle–cell interactions. However, it is often overlooked that a ligand's affinity can be severely impaired by its attachment to the polyethylene glycol (PEG) chains that are frequently used to protect colloids from serum protein adsorption. Using the model ligand EXP3174, a ...

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Item type:Article
Date:August 2014
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1016/j.jconrel.2014.07.062DOI
Keywords:Small molecules; PEGylation; Nanoparticles; Multivalency; Quantum dots; Active targeting
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30699
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