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Nanoparticle multivalency counterbalances the ligand affinity loss upon PEGylation

Hennig, Robert ; Pollinger, Klaus ; Veser, Anika ; Breunig, Miriam ; Goepferich, Achim



Abstract

The conjugation of receptor ligands to shielded nanoparticles is a widely used strategy to precisely control nanoparticle–cell interactions. However, it is often overlooked that a ligand's affinity can be severely impaired by its attachment to the polyethylene glycol (PEG) chains that are frequently used to protect colloids from serum protein adsorption. Using the model ligand EXP3174, a ...

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