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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-307009
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.30700
Alternative Links zum Volltext:DOI
Zusammenfassung
Controlling the activity of sirtuins is of high biomedical relevance as the enzymes are involved in cancer, neurodegeneration and other diseases. Therefore structural elements of 3,4-bisindoylmaleimides (BIMs), which are known NAD+-dependent histone deacetylase (sirtuin) inhibitors, were merged with photochromic diarylmaleimides to yield photoswitchable enzyme inhibitors. The new inhibitors show ...
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