Go to content
UR Home

Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins

URN to cite this document:
urn:nbn:de:bvb:355-epub-307009
Falenczyk, Carolin ; Schiedel, M. ; Karaman, B. ; Rumpf, T. ; Kuzmanovic, Natascha ; Grotli, M. ; Sippl, Wolfgang ; Jung, M. ; König, Burkhard
[img]
Preview
License: Creative Commons Attribution 3.0
PDF - Published Version
(1MB)
Date of publication of this fulltext: 22 Aug 2014 11:59


Abstract

Controlling the activity of sirtuins is of high biomedical relevance as the enzymes are involved in cancer, neurodegeneration and other diseases. Therefore structural elements of 3,4-bisindoylmaleimides (BIMs), which are known NAD+-dependent histone deacetylase (sirtuin) inhibitors, were merged with photochromic diarylmaleimides to yield photoswitchable enzyme inhibitors. The new inhibitors show ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons