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Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins

URN to cite this document:
Falenczyk, Carolin ; Schiedel, M. ; Karaman, B. ; Rumpf, T. ; Kuzmanovic, Natascha ; Grotli, M. ; Sippl, Wolfgang ; Jung, M. ; König, Burkhard
License: Creative Commons Attribution 3.0
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Date of publication of this fulltext: 22 Aug 2014 11:59


Controlling the activity of sirtuins is of high biomedical relevance as the enzymes are involved in cancer, neurodegeneration and other diseases. Therefore structural elements of 3,4-bisindoylmaleimides (BIMs), which are known NAD+-dependent histone deacetylase (sirtuin) inhibitors, were merged with photochromic diarylmaleimides to yield photoswitchable enzyme inhibitors. The new inhibitors show ...


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