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Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins

Falenczyk, Carolin, Schiedel, M., Karaman, B., Rumpf, T., Kuzmanovic, Natascha, Grotli, M., Sippl, Wolfgang, Jung, M. and König, Burkhard (2014) Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins. Chemical Science 5, pp. 4794-4799.

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Date of publication of this fulltext: 22 Aug 2014 11:59

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Abstract

Controlling the activity of sirtuins is of high biomedical relevance as the enzymes are involved in cancer, neurodegeneration and other diseases. Therefore structural elements of 3,4-bisindoylmaleimides (BIMs), which are known NAD+-dependent histone deacetylase (sirtuin) inhibitors, were merged with photochromic diarylmaleimides to yield photoswitchable enzyme inhibitors. The new inhibitors show ...

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Item type:Article
Date:2014
Additional Information (public):Open-Access-Komponente aus der Allianzlizenz
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:GRK 1910, Graduiertenkolleg "Medicinal Chemistry of Selective GPCR Ligands", CRC992
Identification Number:
ValueType
10.1039/C4SC01346HDOI
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30700
Owner only: item control page

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