Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins

URN to cite this document:: urn:nbn:de:bvb:355-epub-307009
DOI to cite this document:: 10.5283/epub.30700

Falenczyk, Carolin ; Schiedel, M. ; Karaman, B. ; Rumpf, T. ; Kuzmanovic, Natascha ; Grotli, M. ; Sippl, Wolfgang ; Jung, M. ; König, Burkhard

Preview

License: Creative Commons: Attribution 3.0
PDF - Published Version
(1MB)

Date of publication of this fulltext: 22 Aug 2014 11:59

Alternative links to fulltext:DOI

Details

Preview

Export bibliographical data

Abstract

Controlling the activity of sirtuins is of high biomedical relevance as the enzymes are involved in cancer, neurodegeneration and other diseases. Therefore structural elements of 3,4-bisindoylmaleimides (BIMs), which are known NAD+-dependent histone deacetylase (sirtuin) inhibitors, were merged with photochromic diarylmaleimides to yield photoswitchable enzyme inhibitors. The new inhibitors show ...