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Die Effekte der Carboanhydrase IX-Inhibition auf die Chemo- und Strahlensensibilität von Glioblastomzellen

Baumgartner, Jana Paulina Teresa (2014) Die Effekte der Carboanhydrase IX-Inhibition auf die Chemo- und Strahlensensibilität von Glioblastomzellen. PhD, Universität Regensburg.

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Date of publication of this fulltext: 01 Sep 2014 13:38

Abstract (German)

Fragestellung: Das Glioblastom, der häufigste hirneigene maligne Tumor im Erwachsenenalter, weist trotz multimodaler Therapie eine schlechte Prognose auf. Ein gesteigerter glykolytischer Metabolismus, intratumorale Hypoxie sowie eine resultierende erhöhte Expression der Carboanhydrase IX sind charakteristische Merkmale des Glioblastoms. Die CAIX ist in die Regulation des tumoralen pHs ...


Translation of the abstract (English)

Purpose: Glioblastoma multiforme is the most frequent primary brain tumor in adults. In spite of multimodal treatment, overall survival is still poor. Malignant gliomas are metabolically characterized by enhanced glycolysis, high degree of intratumoral hypoxia resulting in high CAIX expression levels compared to the normal brain. Despite increased glycolytic metabolism leading to significant ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:1 September 2014
Referee:PD Dr. Martin Proescholdt
Date of exam:28 August 2014
Institutions:Medicine > Lehrstuhl für Neurochirurgie
Keywords:glioblastoma multiforme, hypoxia, CAIX, pH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30708
Owner only: item control page


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