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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-308961
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.30896
Zusammenfassung
Signal transducer and activator of transcription STAT5 and its upstream activating kinase JAK2 are essential mediators of cytokine signaling. Their activity is normally tightly regulated and transient. However, constitutive activation of STAT5 is found in numerous cancers and a driving force for malignant transformation. We describe here the identification of the synthetic chalcone ...
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