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Synthesis of Natural and Non-natural Curcuminoids and their Neuroprotective Activity against Glutamate-induced Oxidative Stress in HT-22 Cells

Jirásek, Petr ; Amslinger, Sabine ; Heilmann, Jörg



Abstract

A strategy for the synthesis of natural and non-natural 5-deoxy-6,7-dihydrocurcuminoids (diarylheptanoids) was developed for the preparation of 14 compounds with varying aromatic substituent patterns and a different functionality in the aliphatic seven-carbon chain. The in vitro protective activity against glutamate-induced neuronal cell death was examined in the murine hippocampal cell line ...

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