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Synthesis of Natural and Non-natural Curcuminoids and their Neuroprotective Activity against Glutamate-induced Oxidative Stress in HT-22 Cells

Jirásek, Petr, Amslinger, Sabine and Heilmann, Jörg (2014) Synthesis of Natural and Non-natural Curcuminoids and their Neuroprotective Activity against Glutamate-induced Oxidative Stress in HT-22 Cells. J. Nat. Prod. 77, pp. 2206-2217.

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Abstract

A strategy for the synthesis of natural and non-natural 5-deoxy-6,7-dihydrocurcuminoids (diarylheptanoids) was developed for the preparation of 14 compounds with varying aromatic substituent patterns and a different functionality in the aliphatic seven-carbon chain. The in vitro protective activity against glutamate-induced neuronal cell death was examined in the murine hippocampal cell line ...

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Item type:Article
Date:2014
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Identification Number:
ValueType
10.1021/np500396yDOI
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30898
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