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Enhancing the anti-inflammatory activity of chalcones by tuning the Michael acceptor site

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Rücker, Hannelore ; Al-Rifai, Nafisah ; Rascle, Anne ; Gottfried, Eva ; Brodziak-Jarosz, Lidia ; Gerhäuser, Clarissa ; Dick, Tobias P. ; Amslinger, Sabine
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Date of publication of this fulltext: 26 Jan 2015 12:54


Inflammatory signaling pathways orchestrate the cellular response to infection and injury. These pathways are known to be modulated by compounds that alkylate cysteinyl thiols. One class of phytochemicals with strong thiol alkylating activity is the chalcones. In this study we tested fourteen chalcone derivatives, α-X-substituted 2’,3,4,4’-tetramethoxychalcones (α-X-TMCs, X = H, F, Cl, Br, I, CN, ...


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