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Subcellular localization of LKB1 and characterization of its interactions with the membrane skeleton in Drosophila melanogaster

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Thiele, Christian Volker Steffen
Date of publication of this fulltext: 08 Jan 2016 12:32

Abstract (English)

Germ line mutations in the human lkb1 gene are the main cause of the Peutz-Jeghers syndrome (Hemminki, 1999) and somatic lkb1 mutations are associated with mainly epithelial cancers (Sanchez-Cespedes, 2007). The serine/threonine kinase LKB1 (STK11) is involved in different cellular processes like cell proliferation, energy homeostasis and cell polarity (Martin-Belmonte and Perez-Moreno, 2012). ...


Translation of the abstract (German)

Keimbahnmutationen des humanen lkb1 Gens sind die Hauptursache des Peutz-Jeghers-Syndroms (Hemminki, 1999) und somatische lkb1 Mutationen sind vor allem mit epithelialem Krebs assoziiert (Sanchez-Cespedes, 2007). Die Serin-/Threonin-Kinase LKB1 (STK11) ist in verschiedenen Zellprozessen beteiligt, wie Zellproliferation, Energiehomöostase und Zellpolarität (Martin-Belmonte and Perez-Moreno, 2012). ...


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