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Subcellular localization of LKB1 and characterization of its interactions with the membrane skeleton in Drosophila melanogaster

Thiele, Christian Volker Steffen (2016) Subcellular localization of LKB1 and characterization of its interactions with the membrane skeleton in Drosophila melanogaster. PhD, Universität Regensburg.

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Date of publication of this fulltext: 08 Jan 2016 12:32

Abstract (English)

Germ line mutations in the human lkb1 gene are the main cause of the Peutz-Jeghers syndrome (Hemminki, 1999) and somatic lkb1 mutations are associated with mainly epithelial cancers (Sanchez-Cespedes, 2007). The serine/threonine kinase LKB1 (STK11) is involved in different cellular processes like cell proliferation, energy homeostasis and cell polarity (Martin-Belmonte and Perez-Moreno, 2012). ...

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Translation of the abstract (German)

Keimbahnmutationen des humanen lkb1 Gens sind die Hauptursache des Peutz-Jeghers-Syndroms (Hemminki, 1999) und somatische lkb1 Mutationen sind vor allem mit epithelialem Krebs assoziiert (Sanchez-Cespedes, 2007). Die Serin-/Threonin-Kinase LKB1 (STK11) ist in verschiedenen Zellprozessen beteiligt, wie Zellproliferation, Energiehomöostase und Zellpolarität (Martin-Belmonte and Perez-Moreno, 2012). ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:8 January 2016
Referee:Prof. Dr. Michael Krahn
Date of exam:8 July 2014
Institutions:Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie
Keywords:LKB1, Peutz-Jeghers-Syndrome, Spectrin, AMPK, Drosophila melanogaster, Serine-/Threonine-Kinase, farnesylation
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 590 Zoological sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:31340
Owner only: item control page

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