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In vitro reconstitution of yeast tUTP/UTP A and UTP B subcomplexes provides new insights into their modular architecture.

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Perez-Fernandez, Jorge ; Pöll, Gisela ; Li, Shuang ; Ohmayer, Uli ; Hierlmeier, Thomas ; Milkereit, Philipp
Date of publication of this fulltext: 23 Feb 2015 11:36


Eukaryotic ribosome biogenesis is a multistep process involving more than 150 biogenesis factors, which interact transiently with pre-ribosomal particles to promote their maturation. Some of these auxiliary proteins have been isolated in complexes found separate from the ribosomal environment. Among them, are 3 large UTP subcomplexes containing 6 or 7 protein subunits which are involved in the ...


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