CYB5A polymorphism increases androgens and reduces risk of rheumatoid arthritis in women

URN to cite this document:: urn:nbn:de:bvb:355-epub-314995

Straub, Rainer H. ; Stark, Klaus ; Rovenský, Jozef ; Blažičková, Stanislava ; Eiselt, Gabriele ; Schmidt, Martin

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Date of publication of this fulltext: 20 Mar 2015 12:51

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Abstract

Introduction Rheumatoid arthritis (RA) is characterized by decreased androgen levels, which was the first hormonal abnormality described. Several studies indicated that steroidogenesis is directed towards endogenous glucocorticoids at the expense of androgens. The decisive step governing androgen synthesis is the 17,20-lyase activity of the CYP17A1 gene-encoded enzyme cytochrome P450 17A1. Here, ...