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CYB5A polymorphism increases androgens and reduces risk of rheumatoid arthritis in women

Straub, Rainer H., Stark, Klaus, Rovenský, Jozef, Blažičková, Stanislava, Eiselt, Gabriele and Schmidt, Martin (2015) CYB5A polymorphism increases androgens and reduces risk of rheumatoid arthritis in women. Arthritis Research & Therapy 17 (56), pp. 1-11.

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Date of publication of this fulltext: 20 Mar 2015 12:51

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Other URL: http://arthritis-research.com/content/17/1/56/abstract


Abstract

Introduction Rheumatoid arthritis (RA) is characterized by decreased androgen levels, which was the first hormonal abnormality described. Several studies indicated that steroidogenesis is directed towards endogenous glucocorticoids at the expense of androgens. The decisive step governing androgen synthesis is the 17,20-lyase activity of the CYP17A1 gene-encoded enzyme cytochrome P450 17A1. Here, ...

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Item type:Article
Date:11 March 2015
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s13075-015-0574-9DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:31499
Owner only: item control page

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