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Acetylcholinesterase Inhibitors with Photoswitchable Inhibition of β‑Amyloid Aggregation

Chen, Xinyu ; Wehle, Sarah ; Kuzmanovic, Natascha ; Merget, Benjamin ; Holzgrabe, Ulrike ; König, Burkhard ; Sotriffer, Christoph A. ; Decker, Michael



Abstract

Photochromic cholinesterase inhibitors were obtained from cis-1,2-α-dithienylethene-based compounds by incorporating one or two aminopolymethylene tacrine groups. All target compounds are potent acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors in the nanomolar concentration range. Compound 11b bearing an octylene linker exhibited interactions with both the catalytic active site (CAS) ...

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