Chen, Xinyu, Wehle, Sarah, Kuzmanovic, Natascha, Merget, Benjamin, Holzgrabe, Ulrike, König, Burkhard, Sotriffer, Christoph A. and Decker, Michael (2014) Acetylcholinesterase Inhibitors with Photoswitchable Inhibition of β‑Amyloid Aggregation. ACS Chemical Neuroscience 5, pp. 377-389.
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Abstract
Photochromic cholinesterase inhibitors were obtained from cis-1,2-α-dithienylethene-based compounds by incorporating one or two aminopolymethylene tacrine groups. All target compounds are potent acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors in the nanomolar concentration range. Compound 11b bearing an octylene linker exhibited interactions with both the catalytic active site (CAS) ...
Export bibliographical data
| Item type: | Article | ||||||
|---|---|---|---|---|---|---|---|
| Date: | 2014 | ||||||
| Institutions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König | ||||||
| Projects: | DFG DE1546/6-1 | ||||||
| Identification Number: |
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| Keywords: | Alzheimer’s disease, beta-amyloid aggregation, cholinesterase inhibitors, tacrine, photochromism, 1,2-dithienylethene | ||||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences | ||||||
| Status: | Published | ||||||
| Refereed: | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg: | Yes | ||||||
| Item ID: | 31509 |
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