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Chromatin remodelers: from function to dysfunction

URN to cite this document:
urn:nbn:de:bvb:355-epub-319522
Längst, Gernot ; Manelyte, Laura
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Date of publication of this fulltext: 16 Jun 2015 09:54


Abstract

Chromatin remodelers are key players in the regulation of chromatin accessibility and nucleosome positioning on the eukaryotic DNA, thereby essential for all DNA dependent biological processes. Thus, it is not surprising that upon of deregulation of those molecular machines healthy cells can turn into cancerous cells. Even though the remodeling enzymes are very abundant and a multitude of ...

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