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Analysis of individual enzyme molecules in large arrays of femtoliter-sized reaction chambers

URN to cite this document:
urn:nbn:de:bvb:355-epub-319790
DOI to cite this document:
10.5283/epub.31979
Liebherr, Raphaela Barbara
Date of publication of this fulltext: 24 Jun 2015 11:34


Abstract (English)

The aim of this thesis was the analysis of individual enzyme molecules in large arrays of homogeneously arranged femtoliter-sized reaction chambers. The implementation of single molecule technologies in bioanalytical research provides us with new insights into the basic principles of life, revealing interesting details of biomolecular interactions. Thus, different conformational states or ...

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Translation of the abstract (German)

Ziel dieser Arbeit war die Untersuchung individueller Enzymmoleküle in großen Arrays aus homogen angeordneten Kammern im Femtoliter-Maßstab. Die Etablierung von Einzelmolekültechniken in der bioanalytischen Forschung eröffnet uns neue Erkenntnisse zu den grundlegenden Prozessen des Lebens. Faszinierende Details zu intermolekularen Wechselwirkungen werden sichtbar gemacht und ...

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