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Verbesserte Wirksamkeit der FGFR Blockade durch mTOR Inhibition im HCC Modell

Scheller, Tobias Philipp (2016) Verbesserte Wirksamkeit der FGFR Blockade durch mTOR Inhibition im HCC Modell. PhD, Universität Regensburg.

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Date of publication of this fulltext: 02 Aug 2016 05:21

Abstract (German)

Einleitung und Zielsetzung Das hepatozelluläre Karzinom (HCC) stellt eine Tumorentität dar, die zu den führenden krebsbedingten Todesursachen zählt. Trotz intensiver Forschung blieben bisherige Versuche systemischer Therapien allerdings weitgehend erfolglos. Ziel unserer Untersuchung war die Analyse der „fibroblast growth factor“ Rezeptor (FGFR) Blockade mit dem „small molecule“ Inhibitor BGJ398 ...

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Translation of the abstract (English)

Background: Systemic therapy has proven only marginal effects in hepatocellular carcinoma (HCC) so far. The aim of this study was to evaluate the effect of targeting fibroblast growth factor receptor (FGFR) on tumour and stromal cells in HCC models. Methods: Human and murine HCC cells, endothelial cells (ECs), vascular smooth muscle cells (VSMCs), hepatic stellate cells (HSCs), human HCC ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:2 August 2016
Referee:PD Dr. Sven A. Lang
Date of exam:23 July 2015
Institutions:Medicine > Lehrstuhl für Chirurgie
Keywords:FGFR inhibition, mTOR, HCC
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:32255
Owner only: item control page

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