Importin-β facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels

URN to cite this document:: urn:nbn:de:bvb:355-epub-323605
DOI to cite this document:: 10.5283/epub.32360

Meister, Gunter ; Schindler, Susann G. ; Danner, Johannes ; Kremmer, Elisabeth ; Pfaff, Janina ; Hannus, Stefan ; Depping, Reinhard ; Schraivogel, Daniel

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Date of publication of this fulltext: 19 Aug 2015 15:28

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Abstract

MicroRNAs (miRNAs) guide Argonaute (Ago) proteins to distinct target mRNAs leading to translational repression and mRNA decay. Ago proteins interact with a member of the GW protein family, referred to as TNRC6A-C in mammals, which coordinate downstream gene-silencing processes. The cytoplasmic functions of TNRC6 and Ago proteins are reasonably well established. Both protein families are found in ...