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Identification and characterization of LMX1B target genes

Stepanova, Natalya (2016) Identification and characterization of LMX1B target genes. PhD, Universität Regensburg.

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Date of publication of this fulltext: 01 Aug 2016 05:59

Abstract (English)

Mutations in the LMX1B gene are associated with a rare autosomal-dominant disorder called nail-patella syndrome which affects limbs, eyes, brain and kidneys. The main LMX1B targets in kidneys are the foot processes and slit diaphragms of podocytes. In search for the genes which are regulated by LMX1B, microarray studies on glomeruli isolated from inducible podocyte-specific Lmx1b knock-out mice ...

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Translation of the abstract (German)

Mutationen im LMX1B Gen sind mit einer autosomal-dominanten Erkrankung namens Nagel-Patella-Syndrom verbunden, die Gliedmaßen, Augen, Gehirn und Nieren beeinflusst. Hauptziele von LMX1B in den Nieren sind die Fussfortsätze und Schlitzmembran der Podozyten. Auf der Suche nach den Genen die durch LMX1B reguliert sind, wurden Microarray-Studien an Glomeruli durchgeführt, welche aus induzierbaren ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:1 August 2016
Referee:Prof. Dr. Ralph Witzgall
Date of exam:30 July 2015
Institutions:Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie > Prof. Dr. Ralph Witzgall
Keywords:LMX1B, Abra, Arl4c, Crct1, podocyte, actin cytoskeleton
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:32372
Owner only: item control page

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