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Autodisplay of human hyaluronidase Hyal-1 on Escherichia coli and identification of plant-derived enzyme inhibitors

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Orlando, Zoya ; Lengers, Isabelle ; Melzig, Matthias F. ; Buschauer, Armin ; Hensel, Andreas ; Jose, Joachim
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Date of publication of this fulltext: 27 Aug 2015 09:04


Hyaluronan (HA) is the main component of the extracellular matrix (ECM). Depending on its chain size, it is generally accepted to exert diverse effects. High molecular weight HA is anti-angiogenic, immunosuppressive and anti-inflammatory, while lower fragments are angiogenic and inflammatory. Human hyaluronidase Hyal-1 (Hyal-1) is one of the main enzymes in the metabolism of HA. This makes Hyal-1 ...


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