Autodisplay of human hyaluronidase Hyal-1 on Escherichia coli and identification of plant-derived enzyme inhibitors

URN to cite this document:: urn:nbn:de:bvb:355-epub-323795
DOI to cite this document:: 10.5283/epub.32379

Orlando, Zoya ; Lengers, Isabelle ; Melzig, Matthias F. ; Buschauer, Armin ; Hensel, Andreas ; Jose, Joachim

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Date of publication of this fulltext: 27 Aug 2015 09:04

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Abstract

Hyaluronan (HA) is the main component of the extracellular matrix (ECM). Depending on its chain size, it is generally accepted to exert diverse effects. High molecular weight HA is anti-angiogenic, immunosuppressive and anti-inflammatory, while lower fragments are angiogenic and inflammatory. Human hyaluronidase Hyal-1 (Hyal-1) is one of the main enzymes in the metabolism of HA. This makes Hyal-1 ...