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Diels-​Alder hydrogels with enhanced stability: First step toward controlled release of bevacizumab

Kirchhof, Susanne, Gregoritza, Manuel, Messmann, Viktoria, Hammer, Nadine, Göpferich, Achim and Brandl, Ferdinand (2015) Diels-​Alder hydrogels with enhanced stability: First step toward controlled release of bevacizumab. European Journal of Pharmaceutics and Biopharmaceutics 96, pp. 217-225.

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Abstract

Eight-armed PEG was functionalized with furyl and maleimide groups (8armPEG20k-Fur and 8armPEG20k-Mal); degradable hydrogels were obtained by cross-linking via Diels–Alder chemistry. To increase the stability to degradation, the macromonomers were modified by introducing a hydrophobic 6-aminohexanoic acid spacer between PEG and the reactive end-groups (8armPEG20k-Ahx-Fur and 8armPEG20k-Ahx-Mal). ...

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Item type:Article
Date:2015
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1016/j.ejpb.2015.07.024DOI
Keywords:Diels–Alder reaction; Poly(ethylene glycol); Hydrogel; Degradation; Bevacizumab; Controlled release
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:32380
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