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Diels-​Alder hydrogels with enhanced stability: First step toward controlled release of bevacizumab

Kirchhof, Susanne ; Gregoritza, Manuel ; Messmann, Viktoria ; Hammer, Nadine ; Göpferich, Achim ; Brandl, Ferdinand



Zusammenfassung

Eight-armed PEG was functionalized with furyl and maleimide groups (8armPEG20k-Fur and 8armPEG20k-Mal); degradable hydrogels were obtained by cross-linking via Diels-Alder chemistry. To increase the stability to degradation, the macromonomers were modified by introducing a hydrophobic 6-aminohexanoic acid spacer between PEG and the reactive end-groups (8armPEG20k-Ahx-Fur and 8armPEG20k-Ahx-Mal). ...

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