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Diels–Alder hydrogels for controlled antibody release: Correlation between mesh size and release rate

Kirchhof, Susanne, Abrami, Michela, Messmann, Viktoria, Hammer, Nadine, Goepferich, Achim, Grassi, Mario and Brandl, Ferdinand (2015) Diels–Alder hydrogels for controlled antibody release: Correlation between mesh size and release rate. Molecular Pharmaceutics 12 (9), pp. 3358-3368.

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Abstract

Eight-armed PEG, molecular mass 10 kDa, was functionalized with furyl and maleimide groups, respectively; the obtained macromonomers were cross-linked via Diels–Alder chemistry. The mesh size (ξ) of the prepared hydrogels was determined by swelling studies, rheology, and low field NMR spectroscopy. The in vitro release of fluorescein isothiocyanate labeled dextrans (FDs) and bevacizumab was ...

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Item type:Article
Date:2015
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1021/acs.molpharmaceut.5b00375DOI
Keywords:Diels−Alder; hydrogel; mesh size; controlled release; antibody
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:32561
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