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Analysis of Argonaute-Chromatin Interactions in Human Somatic Cells

Strieder, Nicholas (2016) Analysis of Argonaute-Chromatin Interactions in Human Somatic Cells. PhD, Universität Regensburg.

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Date of publication of this fulltext: 06 Oct 2016 05:27

Abstract (English)

A main regulator of mRNA abunance in the cell are Argonaute (Ago) proteins. Agos are guided by an associating small RNA molecule to complementary mRNAs in the cytoplasm resulting in their translational repression and degradation. Apart from their cytoplasmic function which is conserved across many species, some Ago proteins were also found to influence mRNA abundance at the step of transcription ...

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Translation of the abstract (German)

Argonatue Proteine (Agos) sind wichtige Regulatoren der mRNA Konzentration im Cytoplasma. Um eine mRNA zu erkennen assoziieren Agos mit kurzen RNA Molekülen (small RNAs ~21 nt), die komplementär zur Ziel-mRNA sind und mit dieser Basenpaare bilden können. Nachdem Ago an eine mRNA gebunden hat, rekrutiert es weitere Faktoren die zur translationellen Repression und mRNA Degradation ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:September 2016
Referee:Prof. Dr. Gunter Meister
Date of exam:13 October 2015
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie
Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I
Keywords:Argonaute, Ago, chromatin, DAM-ID, DAMID, nucleus
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:32713
Owner only: item control page

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