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A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population.

Sekula, Peggy, Goek, Oemer-Necmi, Quaye, Lydia, Barrios, Clara, Levey, Andrew S., Römisch-Margl, Werner, Menni, Cristina, Yet, Idil, Gieger, Christian, Inker, Lesley A., Adamski, Jerzy, Gronwald, Wolfram, Illig, Thomas, Dettmer, Katja, Krumsiek, Jan, Oefner, Peter J., Valdes, Ana M., Meisinger, Christa, Coresh, Josef, Spector, Tim D., Mohney, Robert P., Suhre, Karsten, Kastenmüller, Gabi and Köttgen, Anna (2015) A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population. Journal of the American Society of Nephrology (JASN) 27 (4), pp. 1175-1188.

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Date of publication of this fulltext: 12 Nov 2015 14:46

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Abstract

Small molecules are extensively metabolized and cleared by the kidney. Changes in serum metabolite concentrations may result from impaired kidney function and can be used to estimate filtration (e.g., the established marker creatinine) or may precede and potentially contribute to CKD development. Here, we applied a nontargeted metabolomics approach using gas and liquid chromatography coupled to ...

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Item type:Article
Date:8 October 2015
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
10.1681/ASN.2014111099DOI
Keywords:metabolites; methods
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:32746
Owner only: item control page

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