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A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population.

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Sekula, Peggy ; Goek, Oemer-Necmi ; Quaye, Lydia ; Barrios, Clara ; Levey, Andrew S. ; Römisch-Margl, Werner ; Menni, Cristina ; Yet, Idil ; Gieger, Christian ; Inker, Lesley A. ; Adamski, Jerzy ; Gronwald, Wolfram ; Illig, Thomas ; Dettmer, Katja ; Krumsiek, Jan ; Oefner, Peter J. ; Valdes, Ana M. ; Meisinger, Christa ; Coresh, Josef ; Spector, Tim D. ; Mohney, Robert P. ; Suhre, Karsten ; Kastenmüller, Gabi ; Köttgen, Anna
Date of publication of this fulltext: 12 Nov 2015 14:46


Small molecules are extensively metabolized and cleared by the kidney. Changes in serum metabolite concentrations may result from impaired kidney function and can be used to estimate filtration (e.g., the established marker creatinine) or may precede and potentially contribute to CKD development. Here, we applied a nontargeted metabolomics approach using gas and liquid chromatography coupled to ...


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