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Distinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolism.

Leisz, Sandra, Schulz, Kristin, Erb, Susanne, Oefner, Peter J., Dettmer, Katja, Mougiakakos, Dimitrios, Wang, Ena, Marincola, Francesco M., Stehle, Franziska and Seliger, Barbara (2015) Distinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolism. Oncotarget 6 (13), pp. 11395-11406.

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Date of publication of this fulltext: 13 Nov 2015 14:36

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Abstract

During the last decade the knowledge about the molecular mechanisms of the cellular adaption to hypoxia and the function of the ``von Hippel Lindau'' (VHL) protein in renal cell carcinoma (RCC) has increased, but there exists little information about the overlap and differences in gene/protein expression of both processes. Therefore the aim of this study was to dissect VHL- and hypoxia-regulated ...

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Item type:Article
Date:27 March 2015
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
25890500PubMed ID
10.18632/oncotarget.3456DOI
Keywords:hypoxia, von Hippel Lindau gene, renal cell carcinoma, cell metabolism, aerobic glycolysis
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:32754
Owner only: item control page

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