Distinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolism.

URN to cite this document:: urn:nbn:de:bvb:355-epub-327545
DOI to cite this document:: 10.5283/epub.32754

Leisz, Sandra ; Schulz, Kristin ; Erb, Susanne ; Oefner, Peter J.

; Dettmer, Katja

; Mougiakakos, Dimitrios ; Wang, Ena ; Marincola, Francesco M. ; Stehle, Franziska ; Seliger, Barbara

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Date of publication of this fulltext: 13 Nov 2015 14:36

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Abstract

During the last decade the knowledge about the molecular mechanisms of the cellular adaption to hypoxia and the function of the "von Hippel Lindau" (VHL) protein in renal cell carcinoma (RCC) has increased, but there exists little information about the overlap and differences in gene/protein expression of both processes. Therefore the aim of this study was to dissect VHL- and hypoxia-regulated ...