Distinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolism.

URN to cite this document:: urn:nbn:de:bvb:355-epub-327545
DOI to cite this document:: 10.5283/epub.32754

Leisz, Sandra ; Schulz, Kristin ; Erb, Susanne ; Oefner, Peter J. ; Dettmer, Katja ; Mougiakakos, Dimitrios ; Wang, Ena ; Marincola, Francesco M. ; Stehle, Franziska ; Seliger, Barbara

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Date of publication of this fulltext: 13 Nov 2015 14:36

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Abstract

During the last decade the knowledge about the molecular mechanisms of the cellular adaption to hypoxia and the function of the ``von Hippel Lindau'' (VHL) protein in renal cell carcinoma (RCC) has increased, but there exists little information about the overlap and differences in gene/protein expression of both processes. Therefore the aim of this study was to dissect VHL- and hypoxia-regulated ...