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Metabolic plasticity of human T cells: Preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2-deoxy-glucose affects effector functions.

Renner, Kathrin ; Geiselhöringer, Anna-Lena ; Fante, Matthias ; Bruss, Christina ; Färber, Stephanie ; Schönhammer, Gabriele ; Peter, Katrin ; Singer, Katrin ; Andreesen, Reinhard ; Hoffmann, Petra ; Oefner, Peter J. ; Herr, Wolfgang ; Kreutz, Marina



Abstract

The strong link between T-cell metabolism and effector functions is well characterized in the murine system but hardly investigated in human T cells. Therefore, we analyzed glycolytic and mitochondrial activity in correlation to function in activated human CD4 and CD8 T cells. Glycolysis was barely detectable upon stimulation but accelerated beyond 24 h, whereas mitochondrial activity was ...

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