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Metabolic plasticity of human T cells: Preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2-deoxy-glucose affects effector functions.

Renner, Kathrin, Geiselhöringer, Anna-Lena, Fante, Matthias, Bruss, Christina, Färber, Stephanie, Schönhammer, Gabriele, Peter, Katrin, Singer, Katrin, Andreesen, Reinhard, Hoffmann, Petra, Oefner, Peter J., Herr, Wolfgang and Kreutz, Marina (2015) Metabolic plasticity of human T cells: Preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2-deoxy-glucose affects effector functions. Eur J Immunol 45 (9), pp. 2504-2516.

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Abstract

The strong link between T-cell metabolism and effector functions is well characterized in the murine system but hardly investigated in human T cells. Therefore, we analyzed glycolytic and mitochondrial activity in correlation to function in activated human CD4 and CD8 T cells. Glycolysis was barely detectable upon stimulation but accelerated beyond 24 h, whereas mitochondrial activity was ...

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Item type:Article
Date:20 July 2015
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Medicine > Regensburger Centrum für Interventionelle Immunologie (RCI)
Identification Number:
ValueType
10.1002/eji.201545473DOI
26114249PubMed ID
Keywords:2-deoxy-glucose;ATP;Cytokines;Glucose deprivation;Human CD4 T cells;Human CD8 T cells;Metabolism;Mitochondrial inhibition
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:32756
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