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Enhanced metabolite profiling using a redesigned atmospheric pressure chemical ionization source for gas chromatography coupled to high-resolution time-of-flight mass spectrometry.

Wachsmuth, Christian J., Hahn, Thomas A., Oefner, Peter J. and Dettmer, Katja (2015) Enhanced metabolite profiling using a redesigned atmospheric pressure chemical ionization source for gas chromatography coupled to high-resolution time-of-flight mass spectrometry. Anal Bioanal Chem (Analytical and Bioanalytical Chemistry) 407 (22), pp. 6669-6680.

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Abstract

An improved atmospheric pressure chemical ionization (APCI II) source for gas chromatography-high-resolution time-of-flight mass spectrometry (GC-HRTOFMS) was compared to its first-generation predecessor for the analysis of fatty acid methyl esters, methoxime-trimethylsilyl derivatives of metabolite standards, and cell culture supernatants. Reductions in gas turbulences and chemical background as ...

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Item type:Article
Date:21 June 2015
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
10.1007/s00216-015-8824-xDOI
26092404PubMed ID
Keywords:GC–APCI–HRTOFMS Ionization efficiency Atmospheric pressure chemical ionization GC–APCI II source Metabolomics
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:32757
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