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Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells

Clara, Renan Orsati, Assmann, Nadine, Ramos Moreno, Ana Carolina, Coimbra, Janine Baptista, Nurenberger, Nadine, Dettmer-Wilde, Katja, Oefner, Peter and Campa, Ana (2015) Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells. Biological Chemistry )Biol Chem. (In Press)

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Abstract

A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-γ (IFN-γ) and related to poor prognosis in melanomas. Besides its role in cancer, IFN-γ plays a key role in the control of pigmentation homeostasis. Here we measured KP metabolites in human melanoma lines ...

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Item type:Article
Date:31 October 2015
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
26524378PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:In Press
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:32819
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