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Characterization of Dnmt1 Binding and DNA Methylation on Nucleosomes and Nucleosomal Arrays

URN to cite this document:
urn:nbn:de:bvb:355-epub-330079
Längst, Gernot ; Schrader, Anna ; Gross, Thomas ; Thalhammer, Verena
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Date of publication of this fulltext: 07 Dec 2015 12:50


Abstract

The packaging of DNA into nucleosomes and the organisation into higher order structures of chromatin limits the access of sequence specific DNA binding factors to DNA. In cells, DNA methylation is preferentially occuring in the linker region of nucleosomes, suggesting a structural impact of chromatin on DNA methylation. These observations raise the question whether DNA methyltransferases are ...

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