In vitro myotoxic effects of bupivacaine on rhabdomyosarcoma cells, immortalized and primary muscle cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-330415
DOI to cite this document:: 10.5283/epub.33041

Metterlein, Thomas ; Hoffmann, Petra ; Späth, Ruth ; Gruber, Michael ; Graf, Bernhard M. ; Zing, Wolfgang

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Date of publication of this fulltext: 11 Dec 2015 11:59

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Abstract

Background Rhabdomyosarcoma is a rare malignant skeletal muscle tumor. It mainly occurs in children and young adults and has an unsatisfactory prognosis. Prior studies showed a direct myotoxic effect of bupivacaine on differentiated muscle cells in vitro and in vivo. Exact mechanisms of this myotoxicity are still not fully understood, but a myotoxic effect on malignant muscle tumor cells has not ...