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Identification of Plasma Metabolites Prognostic of Acute Kidney Injury after Cardiac Surgery with Cardiopulmonary Bypass

Zacharias, Helena ; Hochrein, Jochen ; Vogl, Franziska C. ; Schley, G. ; Mayer, F. ; Jeleazcov, C. ; Eckardt, K. U. ; Willam, C. ; Oefner, Peter J. ; Gronwald, Wolfram


Acute kidney injury (AKI) is a frequent complication after cardiopulmonary bypass, but early detection of postoperative AKI remains challenging. Protein biomarkers predict AKI excellently in homogeneous cohorts but are less reliable in patients suffering from various comorbidities. We employed nuclear magnetic resonance spectroscopy in a prospective study of 85 adult cardiac surgery patients to ...


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