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Identification of Plasma Metabolites Prognostic of Acute Kidney Injury after Cardiac Surgery with Cardiopulmonary Bypass

Zacharias, Helena, Hochrein, Jochen, Vogl, Franziska C., Schley, G., Mayer, F., Jeleazcov, C., Eckardt, K. U., Willam, C., Oefner, Peter J. and Gronwald, Wolfram (2015) Identification of Plasma Metabolites Prognostic of Acute Kidney Injury after Cardiac Surgery with Cardiopulmonary Bypass. J. Proteome Res. 14 (7), pp. 2897-2905.

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Abstract

Acute kidney injury (AKI) is a frequent complication after cardiopulmonary bypass, but early detection of postoperative AKI remains challenging. Protein biomarkers predict AKI excellently in homogeneous cohorts but are less reliable in patients suffering from various comorbidities. We employed nuclear magnetic resonance spectroscopy in a prospective study of 85 adult cardiac surgery patients to ...

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Item type:Article
Date:July 2015
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
10.1021/acs.jproteome.5b00219DOI
Keywords:acute kidney injury; AKI; metabolomics; NMR spectroscopy; prognostication; molecular signature
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33524
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