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The Microbiome and Allogeneic Stem Cell Transplantation

Sporrer, Daniela ; Gessner, Andre ; Hehlgans, Thomas ; Oefner, Peter J. ; Holler, Ernst


Graft-versus-host disease (GvHD) is the major cause of mortality and morbidity after allogeneic stem cell transplantation. Recently, deep sequencing of the hypervariable regions of the 16S rRNA gene in stool specimens significantly enhanced our understanding of a likely pathophysiologic role of the microbiome in GvHD. Here, we summarize the indirect and direct evidence for a microbiome ...


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