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Characterization of nucleolus-associated chromatin domains during cellular aging and upon genetic inactivation of the Upstream Binding Factor protein

Dillinger, Stefan (2016) Characterization of nucleolus-associated chromatin domains during cellular aging and upon genetic inactivation of the Upstream Binding Factor protein. PhD, Universität Regensburg.

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Date of publication of this fulltext: 07 Apr 2016 11:23

Abstract (English)

The nucleus of mammalian cells consists of several structural and functional domains, of which the nucleolus is the largest one. Although its primary function in the synthesis of ribosomal RNA and early steps of ribosome assembly is well characterized and its role in stress sensing, cell cycle regulation and RNA modification has been revealed, the involve- ment of the nucleolus in genome ...

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Translation of the abstract (German)

Der Nukleolus ist die Gr ̈oßte von verschiedenen strukturellen und funktionellen Dom ̈anen im Kern von S ̈augetierzellen. Obwohl seine prim ̈are Funktion, die Synthese ribosomaler RNA und fru ̈he Schritte der Ribosomenassemblierung gut beschrieben sind und seine Rolle in der Stresswahrnehmung, Zellzyklusregulierung und RNA Modifikation beschrieben wu- rde, ist wenig u ̈ber seine Rolle im Bezug ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:7 April 2016
Referee:PD Dr. Attila Németh
Date of exam:10 March 2016
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie
Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > House of the Ribosome
Keywords:Aging, Nucleolus, Nuclear Architecutre
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33550
Owner only: item control page

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