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Characterization of nucleolus-associated chromatin domains during cellular aging and upon genetic inactivation of the Upstream Binding Factor protein

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Dillinger, Stefan
Date of publication of this fulltext: 07 Apr 2016 11:23

Abstract (English)

The nucleus of mammalian cells consists of several structural and functional domains, of which the nucleolus is the largest one. Although its primary function in the synthesis of ribosomal RNA and early steps of ribosome assembly is well characterized and its role in stress sensing, cell cycle regulation and RNA modification has been revealed, the involve- ment of the nucleolus in genome ...


Translation of the abstract (German)

Der Nukleolus ist die Gr ̈oßte von verschiedenen strukturellen und funktionellen Dom ̈anen im Kern von S ̈augetierzellen. Obwohl seine prim ̈are Funktion, die Synthese ribosomaler RNA und fru ̈he Schritte der Ribosomenassemblierung gut beschrieben sind und seine Rolle in der Stresswahrnehmung, Zellzyklusregulierung und RNA Modifikation beschrieben wu- rde, ist wenig u ̈ber seine Rolle im Bezug ...


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