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Decomposition of 1-(w-aminoalkanoyl)guanidines under alkaline conditions

Brennauer, Albert ; Keller, Max ; Freund, Matthias ; Bernhardt, Günther ; Buschauer, Armin


The decomposition of some NG-(ω-aminoalkanoyl)argininamides, which are key intermediates for the preparation of radiolabeled and fluorescent neuropeptide Y receptor ligands, prompted us to synthesize a small series of simple 1-(ω-aminoalkanoyl)guanidines, and to investigate these model compounds for stability in alkaline buffers. The degradation of acylguanidines was monitored by time resolved UV ...


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