Identification of a new gene regulatory circuit involving B cell receptor activated signaling using a combined analysis of experimental, clinical and global gene expression data

URN to cite this document:: urn:nbn:de:bvb:355-epub-337703
DOI to cite this document:: 10.5283/epub.33770

Schrader, A. ; Meyer, Katharina ; Walther, N. ; Stolz, A. ; Feist, M. ; Hand, E. ; Bonin, F. von ; Evers, Maurits ; Kohler, Christian ; Shirneshan, K. ; Vockerodt, M. ; Klapper, W. ; Szczepanowski, M. ; Murray, P. G. ; Bastians, H. ; Trümper, Lorenz ; Spang, Rainer ; Kube, Dieter

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Date of publication of this fulltext: 20 May 2016 07:44

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Abstract

To discover new regulatory pathways in B lymphoma cells, we performed a combined analysis of experimental, clinical and global gene expression data. We identified a specific cluster of genes that was coherently expressed in primary lymphoma samples and suppressed by activation of the B cell receptor (BCR) through aIgM treatment of lymphoma cells in vitro. This gene cluster, which we called BCR. ...