Identification of a new gene regulatory circuit involving B cell receptor activated signaling using a combined analysis of experimental, clinical and global gene expression data

URN to cite this document:

urn:nbn:de:bvb:355-epub-337703 Copy

DOI to cite this document:

10.5283/epub.33770 Copy

Schrader, A. ; Meyer, Katharina ; Walther, N. ; Stolz, A. ; Feist, M. ; Hand, E. ; Bonin, F. von ; Evers, Maurits ; Kohler, Christian ; Shirneshan, K. ; Vockerodt, M. ; Klapper, W. ; Szczepanowski, M. ; Murray, P. G. ; Bastians, H. ; Trümper, Lorenz ; Spang, Rainer ; Kube, Dieter

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Date of publication of this fulltext: 20 May 2016 07:44

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Details

Item type:	Article
Journal or Publication Title:	OncoTarget
Publisher:	IMPACT JOURNALS LLC
Place of Publication:	ORCHARD PARK
Date:	7 May 2016
Institutions:	Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) Informatics and Data Science > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:	Value Type 27166259 PubMed ID 10.18632/oncotarget.9219 DOI
Keywords:	NF-KAPPA-B; BURKITTS-LYMPHOMA; INDUCED APOPTOSIS; DIFFERENTIAL EXPRESSION; PATHWAY ACTIVATION; MEDIATED APOPTOSIS; CYCLE REGULATION; IN-VITRO; MITOSIS; TARGET; lymphoma; B cell receptor signaling; guided clustering; cell cycle delay; chromosomal aberrations
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine 500 Science > 500 Natural sciences & mathematics 600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Partially
Item ID:	33770

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Abstract

To discover new regulatory pathways in B lymphoma cells, we performed a combined analysis of experimental, clinical and global gene expression data. We identified a specific cluster of genes that was coherently expressed in primary lymphoma samples and suppressed by activation of the B cell receptor (BCR) through aIgM treatment of lymphoma cells in vitro. This gene cluster, which we called BCR. ...

Abstract

To discover new regulatory pathways in B lymphoma cells, we performed a combined analysis of experimental, clinical and global gene expression data. We identified a specific cluster of genes that was coherently expressed in primary lymphoma samples and suppressed by activation of the B cell receptor (BCR) through aIgM treatment of lymphoma cells in vitro. This gene cluster, which we called BCR. 1, includes numerous cell cycle regulators. A reduced expression of BCR. 1 genes after BCR activation was observed in different cell lines and also in CD10(+) germinal center B cells. We found that BCR activation led to a delayed entry to and progression of mitosis and defects in metaphase. Cytogenetic changes were detected upon long-term aIgM treatment. Furthermore, an inverse correlation of BCR. 1 genes with c-Myc co-regulated genes in distinct groups of lymphoma patients was observed. Finally, we showed that the BCR. 1 index discriminates activated B cell-like and germinal centre B cell-like diffuse large B cell lymphoma supporting the functional relevance of this new regulatory circuit and the power of guided clustering for biomarker discovery.

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Metadata last modified: 25 Nov 2020 22:41

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