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Design of hydrogels for delayed antibody release utilizing hydrophobic association and Diels-Alder chemistry in tandem

Gregoritza, Manuel, Messmann, Viktoria, Goepferich, Achim and Brandl, Ferdinand (2016) Design of hydrogels for delayed antibody release utilizing hydrophobic association and Diels-Alder chemistry in tandem. Journal of Materials Chemistry B 4 (19), pp. 3398-3408.

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Abstract

Biodegradable hydrogels were prepared from furan- and maleimide-functionalized eight-armed poly(ethylene glycol) with an average molecular mass of 40 000 Da (8armPEG40k-furan and 8armPEG40k-maleimide) using the Diels–Alder (DA) reaction as a cross-linking mechanism. Hydrophobic 6-aminohexanoic acid (C6) and 12-aminododecanoic acid (C12) spacers were introduced between the polymer backbone and the ...

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Item type:Article
Date:2016
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1039/C6TB00223DDOI
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33775
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