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Characterization of the Chromatin Remodeling Enzyme Lymphoid-Specific Helicase

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Gross, Thomas
Date of publication of this fulltext: 02 Jan 2017 06:52

Abstract (English)

Lsh is an essential epigenetic regulator protein and is required for both de novo and maintenance DNA methylation (Zhu et al., 2006) (Myant and Stancheva, 2007) (Dunican et al., 2015). Lsh deficiency results in perturbed heterochromatin structure, abnormal mitosis and de-repression of transcription (Huang, 2004) (Yan et al., 2003b), which is mainly due to a severe decrease in DNA methylation ...


Translation of the abstract (German)

Lsh gehört zur Familie Snf2-ähnlicher ATPasen (Flaus et al., 2006) und ist ein essentieller epigenetischer Regulator. Dabei wird Lsh sowohl für die de novo als auch die maintenance DNA-Methylierung benötigt (Zhu et al., 2006) (Myant and Stancheva, 2007) (Dunican et al., 2015). Das Fehlen von Lsh führt zu anormaler Heterochromatinstruktur, anormaler Mitose und Derepression der Transkription ...


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