Go to content
UR Home

Characterization of the Chromatin Remodeling Enzyme Lymphoid-Specific Helicase

Gross, Thomas (2017) Characterization of the Chromatin Remodeling Enzyme Lymphoid-Specific Helicase. PhD, Universität Regensburg.

[img]
Preview
License: Publishing license for publications including print on demand
PDF
Download (103MB)
Date of publication of this fulltext: 02 Jan 2017 06:52

Abstract (English)

Lsh is an essential epigenetic regulator protein and is required for both de novo and maintenance DNA methylation (Zhu et al., 2006) (Myant and Stancheva, 2007) (Dunican et al., 2015). Lsh deficiency results in perturbed heterochromatin structure, abnormal mitosis and de-repression of transcription (Huang, 2004) (Yan et al., 2003b), which is mainly due to a severe decrease in DNA methylation ...

plus

Translation of the abstract (German)

Lsh gehört zur Familie Snf2-ähnlicher ATPasen (Flaus et al., 2006) und ist ein essentieller epigenetischer Regulator. Dabei wird Lsh sowohl für die de novo als auch die maintenance DNA-Methylierung benötigt (Zhu et al., 2006) (Myant and Stancheva, 2007) (Dunican et al., 2015). Das Fehlen von Lsh führt zu anormaler Heterochromatinstruktur, anormaler Mitose und Derepression der Transkription ...

plus


Export bibliographical data



Item type:Thesis of the University of Regensburg (PhD)
Date:2 January 2017
Referee:Prof. Dr. Gernot Längst
Date of exam:29 April 2016
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Gernot Längst
Keywords:Lymphoid-Specific Helicase, Chromatin remodeling, DNA methylation
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33844
Owner only: item control page

Downloads

Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons