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Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues from Patients

Teufel, Andreas, Itzel, Timo, Erhart, W., Brosch, M., Wang, X. Y., Kim, Y. O., von Schonfels, W., Herrmann, A., Bruckner, S., Stickel, F., Dufour, J. F., Chavakis, T., Hellerbrand, Claus, Spang, Rainer, Maass, Thorsten, Becker, T., Schreiber, S., Schafmayer, C., Schuppan, D. and Hampe, J. (2016) Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues from Patients. Gastroenterology.

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Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Mouse models of NAFLD have been used in studies of pathogenesis and treatment, and have certain features of the human disease. We performed a systematic transcriptome-wide analysis of liver tissues from patients at different stages of NAFLD progression (ranging from healthy obese ...

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Item type:Article
Date:June 2016
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
27318147PubMed ID
10.1053/j.gastro.2016.05.051DOI
Keywords:comparative; cross-species analysis; steatosis; transcriptome
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:33915
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