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L-ascorbic acid-6-hexadecanoate, a potent hyaluronidase inhibitor: X-ray structure and molecular modeling of enzyme-inhibitor complexes.

Botzki, Alexander ; Rigden, Daniel J. ; Braun, Stephan ; Nukui, Masatoshi ; Salmen, Sunnhild ; Hoechstetter, Julia ; Bernhardt, Günther ; Dove, Stefan ; Buschauer, Armin ; Jedrzejas, Mark J.


Hyaluronidases are enzymes that degrade hyaluronan, an important component of the extracellular matrix. The mammalian hyaluronidases are considered to be involved in many (patho)physiological processes like fertilization, tumor growth, and metastasis. Bacterial hyaluronidases, also termed hyaluronate lyases, contribute to the spreading of microorganisms in tissues. Such roles for hyaluronidases ...


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