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Adjusting microbiome profiles for differences in microbial load by spike-in bacteria

Stämmler, Frank, Gläsner, Joachim, Hiergeist, Andreas, Holler, Ernst, Weber, Daniela, Oefner, Peter J., Gessner, Andre and Spang, Rainer (2016) Adjusting microbiome profiles for differences in microbial load by spike-in bacteria. Microbiome 4 (1), p. 28.

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Date of publication of this fulltext: 27 Jun 2016 13:30

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Other URL: http://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-016-0175-0


Abstract

Next-generation 16S ribosomal RNA gene sequencing is widely used to determine the relative composition of the mammalian gut microbiomes. However, in the absence of a reference, this does not reveal alterations in absolute abundance of specific operational taxonomic units if microbial loads vary across specimens.


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Item type:Article
Date:24 June 2016
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s40168-016-0175-0DOI
27329048PubMed ID
Keywords:16S rRNA gene sequencing; Bacterial communities; Community analysis; Microbial load; Microbiome profiling; Spike-in bacteria; Standardization
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33954
Owner only: item control page

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