Fellner, Stephan, Bauer, Björn, Miller, David S., Schaffrick, Martina, Fankhänel, Martina, Spruß, Thilo, Bernhardt, Günther, Graeff, Claudia, Färber, Lothar, Gschaidmeier, Harald, Buschauer, Armin and Fricker, Gert (2002) Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. The Journal of Clinical Investigation 110 (9), pp. 1309-1318.
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Other URL: http://www.jci.org/cgi/content/full/110/9/1309
Abstract
Paclitaxel concentrations in the brain are very low after intravenous injection. Since paclitaxel is excluded from some tumors by p-glycoprotein (p-gp), the same mechanism may prevent entry into the brain. In vitro, paclitaxel transport was examined in capillaries from rat brains by confocal microscopy using BODIPY Fl-paclitaxel. Western blots and immunostaining demonstrated apical expression of ...
Export bibliographical data
| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 2002 | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) | ||||
| Identification Number: |
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| Dewey Decimal Classification: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 3399 |
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