Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

URN to cite this document:: urn:nbn:de:bvb:355-epub-33999
DOI to cite this document:: 10.5283/epub.3399

Fellner, Stephan ; Bauer, Björn ; Miller, David S. ; Schaffrick, Martina ; Fankhänel, Martina ; Spruß, Thilo ; Bernhardt, Günther ; Graeff, Claudia ; Färber, Lothar ; Gschaidmeier, Harald ; Buschauer, Armin ; Fricker, Gert

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Date of publication of this fulltext: 05 Aug 2009 13:42

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Abstract

Paclitaxel concentrations in the brain are very low after intravenous injection. Since paclitaxel is excluded from some tumors by p-glycoprotein (p-gp), the same mechanism may prevent entry into the brain. In vitro, paclitaxel transport was examined in capillaries from rat brains by confocal microscopy using BODIPY Fl-paclitaxel. Western blots and immunostaining demonstrated apical expression of ...