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Quantitative analysis of 5'-deoxy-5'-methylthioadenosine in melanoma cells by liquid chromatography-stable isotope ratio tandem mass spectrometry

Stevens, A. P., Dettmer, Katja, Wallner, S., Bosserhoff, Anja-Katrin and Oefner, Peter J. (2008) Quantitative analysis of 5'-deoxy-5'-methylthioadenosine in melanoma cells by liquid chromatography-stable isotope ratio tandem mass spectrometry. Journal of Chromatography B 876 (1), pp. 123-128.

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Abstract

The frequent deletion of the human chromosomal region 9p21, including the methylthioadenosine phosphorylase (MTAP) gene, is hypothesized to lead to the intra- and/or extracellular accumulation of 5′-deoxy-5′-methylthioadenosine (MTA) in cancer cells and the subsequent promotion of tumor progression. The lack of sensitive methodology for the direct measurement of MTA in tumor cells has hampered ...

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Item type:Article
Date:30 October 2008
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
18996776PubMed ID
10.1016/j.jchromb.2008.10.038DOI
Keywords:5′-Deoxy-5′-methylthioadenosine; Methylthioadenosine phosphorylase; LC–MS/MS; Stable isotope dilution; Melanoma
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34101
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