Absolute configuration of (-)-4-(3,4-dichlorophenyl)-4-(2-pyridyl)butanoic acid: essential information to determine crucial steric feature of arpromidine-type histamine H_2 receptor agonists

Zabel, Manfred, Breu, Josef, Rau, Franz, Range, Klaus-Jürgen, Krey, Volker, Uffrecht, Anka und Buschauer, Armin (2000) Absolute configuration of (-)-4-(3,4-dichlorophenyl)-4-(2-pyridyl)butanoic acid: essential information to determine crucial steric feature of arpromidine-type histamine H_2 receptor agonists. Acta Crystallographica Section C 56, S. 250-251.

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Zusammenfassung

The structural information gained from the study of the chiral building block (R)-(-)-4-(3,4-dichlorophenyl)-4-(2-pyridyl)butanoic acid-L-(-)-ephedrine [methyl(1-hydroxy-1-phenylprop-2-yl)ammonium 4-(3,4-dichlorophenyl)-4-(2-pyridyl)butanoate], C10H16NO+·C15H12Cl2NO2-, can be used to deduce the absolute configuration of highly potent arpromidine-type histamine H2 receptor agonists, as the chiral ...

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