Go to content
UR Home

Stereochemical Investigations on Intermediates for the Synthesis of Histamine H_2 Receptor Agonists and Neuropeptide Y Y_1 Antagonists: Chiral Separation of Phenyl(pyridyl)alkanoic Acids by HPLC and CE

Schuster, Andreas ; Bollwein, Susanne ; Uffrecht, Anka ; Krey, Volker ; Götte, Carsten ; Bernhardt, Günther ; Buschauer, Armin


Abstract

The enantiomeric building blocks for the prepn. of histamine H2 receptor agonists and NPY Y1 antagonists (3-(3,4-difluorophenyl)-3-(2-pyridyl)propanoic acid, 4-(3,4-difluorophenyl)-4-(2-pyridyl)butanoic acid and 4-(3,4-dichlorophenyl)-4-(2-pyridyl)butanoic acid (I)) have been sepd. by HPLC and capillary electrophoresis (CE). On a Chiralpak AD column resolns. of at least 1.5 and selectivities of ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons