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NPY Y_1 antagonists: structure-activity relationships of arginine derivatives and hybrid compounds with arpromidine-like partial structures

Aiglstorfer, Iris ; Uffrecht, Anka ; Geßele, K. ; Moser, Christiane ; Schuster, Andreas ; Merz, S. ; Malawska, B. ; Bernhardt, Günther ; Dove, Stefan ; Buschauer, Armin


Previously, omega-guanidino- and omega-aminoalkanamides, structurally derived from arpromidine-like histamine H2 receptor agonists, were reported as novel neuropeptide Y Y1 antagonists. Regardless of the backbone, they resemble BIBP 3226, an argininamide with high NPY Y1 receptor affinity and selectivity, with respect to nature and arrangement of the 'terminal' diaryl, guanidine, and ...


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