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Combined histamine H_1/H_2 receptor antagonists: Part II. Pharmacological hybrids with pheniramine- and tiotidine-like substructures,

Wolf, Cornelia ; Schulze, Frank R. ; Buschauer, Armin ; Schunack, Walter



Abstract

Hybrid molecules combining the crucial structural features of both pheniramine-type histamine H1 receptor antagonists and guanidinothiazole-type H2 receptor antagonists have been synthesized and tested for in vitro pharmacological activity at the isolated ileum and the spontaneously beating right atrium of the guinea-pig. In the title compounds the basic side chain nitrogen of the H1 antagonist ...

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