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Combined histamine H_1/H_2 receptor antagonists: Part II. Pharmacological hybrids with pheniramine- and tiotidine-like substructures,

Wolf, Cornelia, Schulze, Frank R., Buschauer, Armin and Schunack, Walter (1998) Combined histamine H_1/H_2 receptor antagonists: Part II. Pharmacological hybrids with pheniramine- and tiotidine-like substructures,. European Journal of Pharmaceutical Sciences 6 (3), pp. 187-196.

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Other URL: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T25-3SY9R5P-3&_user=616165&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000032338&_version=1&_urlVersion=0&_userid=616165&md5=404f248da0cf70c69ddeb81f772e89be


Abstract

Hybrid molecules combining the crucial structural features of both pheniramine-type histamine H1 receptor antagonists and guanidinothiazole-type H2 receptor antagonists have been synthesized and tested for in vitro pharmacological activity at the isolated ileum and the spontaneously beating right atrium of the guinea-pig. In the title compounds the basic side chain nitrogen of the H1 antagonist ...

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Item type:Article
Date:1998
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
10.1016/S0928-0987(97)10017-3UNSPECIFIED
Keywords:Histamine; Histamine H1 receptor antagonists; Histamine H2 receptor antagonists; Pheniramine; 2-Guanidinothiazole
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:3418
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